Mechanical stimulation activates Drosophila eggs via Trpm channels
نویسندگان
چکیده
منابع مشابه
TRPM Channels Modulate Epileptic-like Convulsions via Systemic Ion Homeostasis
Neuronal networks operate over a wide range of activity levels, with both neuronal and nonneuronal cells contributing to the balance of excitation and inhibition. Activity imbalance within neuronal networks underlies many neurological diseases, such as epilepsy. The Caenorhabditis elegans locomotor circuit operates via coordinated activity of cholinergic excitatory and GABAergic inhibitory tran...
متن کاملPlasma Membrane Mechanical Stress Activates TRPC5 Channels
Mechanical forces exerted on cells impose stress on the plasma membrane. Cells sense this stress and elicit a mechanoelectric transduction cascade that initiates compensatory mechanisms. Mechanosensitive ion channels in the plasma membrane are responsible for transducing the mechanical signals to electrical signals. However, the mechanisms underlying channel activation in response to mechanical...
متن کاملThe Ca 2 + - Activated TRP Channels : TRPM 4 and TRPM 5
Cloning, Distribution, and Structure of TRPM4 and TRPM5 .............................204 Ion Permeability, Unitary Properties, and Specific Blockers of TRPM4 and TRPM5 .........................................................................................204 Sensitivity of TRPM4 and TRPM5 to Intracellular Ca 2 + .....................................205 Activation of TRPM4 and TRPM5 by Voltage...
متن کاملUrine stimulation activates BK channels in mouse vomeronasal neurons.
Most odor responses in mouse vomeronasal neurons are mediated by the phospholipase C (PLC) pathway, activation of which elevates diacylglycerol (DAG). Lucas et al. showed that DAG activates transient receptor potential channels, subfamily C, member 2 (TRPC2), resulting in a depolarizing Ca2+ influx. DAG can be subsequently converted to arachidonic acid (AA) by a DAG lipase, the role of which re...
متن کاملX-ray irradiation activates K+ channels via H2O2 signaling
Ionizing radiation is a universal tool in tumor therapy but may also cause secondary cancers or cell invasiveness. These negative side effects could be causally related to the human-intermediate-conductance Ca2+-activated-K+-channel (hIK), which is activated by X-ray irradiation and affects cell proliferation and migration. To analyze the signaling cascade downstream of ionizing radiation we us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1913150116